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[0044] FIG. 5A and FIG. 5B show pharmacokinetics of humanized antibody variants in mouse plasma over time.
FIG. 5A demonstrates that five initial humanized antibody variants 2, 5, 6, 9, and 10 exhibited rapid elimination from the mouse plasma.
FIG. 5B demonstrates that three later developed humanized antibody variants L15H11, L46H11, and L47H65 exhibited pharmacokinetics profiles comparable to the chimeric antibody.
[0045] FIG. 6A and FIG. 6B show different humanized antibody variants have different intracerebral migration.
[0046] FIG. 7A and FIG. 7B show alignment of amino acid sequences of the light chain variable region (FIG. 7A) and the heave chain variable region (FIG. 7B) of representative humanized antibody variants with the parent mouse antibody.
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